| 1 |  Shining MewtwoNeo Destiny #109 | $3,000 | $55,797 | $1,178 | +$51,619 | — |
| 2 |  Mewtwo exRuby & Sapphire #101 · 2% gem rate | $311 | $24,231 | $662 | +$23,258 | +$16 |
| 3 |  Mewtwo ☆Holon Phantoms #103 · 5.7% gem rate | $1,769 | $24,497 | $665 | +$22,064 | +$2,397 |
| 4 |  Mewtwo LV.XLegends Awakened #144 · 3.1% gem rate | $276 | $15,000 | $570 | +$14,154 | +$185 |
| 5 |  Armored MewtwoSM Black Star Promos #SM228 · 4.7% gem rate | $253 | $9,318 | $513 | +$8,552 | +$84 |
| 6 |  Mewtwo-GXShining Legends #78 · 16.8% gem rate | $692 | $9,383 | $514 | +$8,177 | +$1,373 |
| 7 |  Rocket's Mewtwo exTeam Rocket Returns #99 · 6.1% gem rate | $1,150 | $9,172 | $512 | +$7,510 | +$645 |
| 8 |  Mewtwo δHolon Phantoms #24 · 5.8% gem rate | $288 | $6,640 | $486 | +$5,866 | −$140 |
| 9 |  Mewtwo δDelta Species #12 · 6.1% gem rate | $385 | $5,803 | $478 | +$4,940 | +$325 |
| 10 |  Mewtwo-EXBREAKthrough #163 · 7.3% gem rate | $169 | $5,015 | $470 | +$4,376 | −$5 |
| 11 |  Rocket's MewtwoGym Challenge #14 | $323 | $5,010 | $470 | +$4,217 | — |
| 12 |  Mewtwo-EXBREAKthrough #164 · 7.6% gem rate | $175 | $4,244 | $237 | +$3,832 | +$150 |
| 13 |  Rocket's MewtwoBest of Game #8 | $500 | $4,250 | $237 | +$3,513 | — |
| 14 |  MewtwoPokémon Rumble #9 · 4.2% gem rate | $550 | $4,131 | $236 | +$3,345 | −$106 |
| 15 |  MewtwoLegendary Treasures #53 · 15.4% gem rate | $33 | $2,750 | $222 | +$2,495 | +$265 |
| 16 |  MewtwoBase #10 · 3% gem rate | $504 | $2,760 | $223 | +$2,033 | +$172 |
| 17 |  Mewtwo-EXBREAKthrough #157 · 11.8% gem rate | $68 | $2,160 | $127 | +$1,966 | +$164 |
| 18 |  Mewtwo-EXBREAKthrough #158 · 17% gem rate | $74 | $2,134 | $126 | +$1,934 | +$281 |
| 19 |  Mewtwo & Mew-GXSM Black Star Promos #SM191 · 50.8% gem rate | $315 | $2,350 | $128 | +$1,907 | +$962 |
| 20 |  M Mewtwo-EXBREAKthrough #159 · 16.5% gem rate | $131 | $2,143 | $126 | +$1,885 | +$252 |
| 21 |  M Mewtwo-EXBREAKthrough #160 · 15.1% gem rate | $145 | $2,010 | $125 | +$1,740 | +$199 |
| 22 |  MewtwoWizards Black Star Promos #12 · 14% gem rate | $130 | $1,828 | $123 | +$1,576 | +$170 |
| 23 |  MewtwoSM Black Star Promos #SM214 · 15.3% gem rate | $17 | $1,576 | $121 | +$1,439 | +$179 |
| 24 |  MewtwoWizards Black Star Promos #3 | $42 | $1,376 | $119 | +$1,216 | — |
| 25 |  Mewtwo & Mew-GXUnified Minds #222 · 34.2% gem rate | $154 | $1,144 | $116 | +$873 | +$243 |
| 26 |  MewtwoExpedition Base Set #20 · 3.5% gem rate | $500 | $1,481 | $120 | +$861 | −$66 |
| 27 |  Team Rocket's Mewtwo exDestined Rivals #231 · 57% gem rate | $557 | $1,496 | $120 | +$819 | +$421 |
| 28 |  Mewtwo & Mew-GXUnified Minds #71 | $117 | $1,039 | $115 | +$807 | — |
| 29 |  Mewtwo-GXShining Legends #76 · 34.9% gem rate | $87 | $879 | $89 | +$703 | +$198 |
| 30 |  MewtwoLegends Awakened #11 · 2.1% gem rate | $109 | $899 | $89 | +$701 | −$4 |
| 31 |  Team Rocket's Mewtwo exAscended Heroes #281 · 69.6% gem rate | $435 | $1,207 | $117 | +$655 | +$436 |
| 32 |  Mewtwo & Mew-GXUnified Minds #242 · 42.9% gem rate | $398 | $1,123 | $116 | +$609 | +$177 |
| 33 |  Mewtwo-EXEvolutions #103 · 27.9% gem rate | $39 | $688 | $87 | +$562 | +$124 |
| 34 |  M Mewtwo-EXBREAKthrough #63 | $19 | $566 | $86 | +$461 | — |
| 35 |  M Mewtwo-EXBREAKthrough #64 | $37 | $579 | $86 | +$457 | — |
| 36 |  Mewtwo-EXXY Black Star Promos #XY107 · 26.1% gem rate | $12 | $529 | $85 | +$431 | +$65 |
| 37 |  MewtwoExpedition Base Set #56 · 6.7% gem rate | $88 | $561 | $86 | +$386 | −$23 |
| 38 |  Mewtwo-EXBREAKthrough #61 | $11 | $469 | $75 | +$383 | — |
| 39 |  MewtwoScarlet & Violet Black Star Promos #52 · 21.1% gem rate | $50 | $480 | $75 | +$355 | +$30 |
| 40 |  Mewtwo VSTARCrown Zenith Galarian Gallery #GG44 · 56.9% gem rate | $306 | $703 | $87 | +$310 | +$151 |
| 41 |  MewtwoLegendary Collection #29 · 2.7% gem rate | $488 | $871 | $89 | +$295 | −$100 |
| 42 |  MewtwoSM Black Star Promos #SM77 | $20 | $360 | $74 | +$266 | — |
| 43 |  Mewtwo-GXShining Legends #72 · 27.4% gem rate | $28 | $356 | $74 | +$254 | +$29 |
| 44 |  Mewtwo-EXBREAKthrough #62 · 26.7% gem rate | $10 | $282 | $73 | +$199 | +$8 |
| 45 |  Mewtwo-GXHidden Fates Shiny Vault #SV59 · 54.3% gem rate | $141 | $398 | $74 | +$183 | +$64 |
| 46 |  MewtwoXY Black Star Promos #XY100 · 2.2% gem rate | $18 | $250 | $72 | +$159 | −$27 |
| 47 |  MewtwoEvolutions #51 | $13 | $234 | $72 | +$149 | — |
| 48 |  Mewtwo-GXSM Black Star Promos #SM196 | $21 | $239 | $72 | +$146 | — |
| 49 |  Mewtwo LV.XDP Black Star Promos #DP28 · 0.6% gem rate | $114 | $320 | $73 | +$133 | −$71 |
| 50 |  MewtwoPokémon TCG Classic - Blastoise #14 · 42.3% gem rate | $28 | $220 | $72 | +$120 | +$10 |